Anti-psychotic Nature of Antibiotics: Vancomycin and Omadacycline Combination Ameliorating Stress in a Zebrafish Model.

Background Stress affects mental health significantly and is a ubiquitous feature of contemporary living. Among the possible antibiotics are omadacycline and vancomycin, whose anti-inflammatory properties have also been thoroughly documented in recent research. The goal of the current study was to examine their complex involvement in the brain's stress response circuits and how they modulate stress. An established model organism that provides a useful platform for examining stress-induced behaviors and possible therapeutic approaches is the zebrafish. To investigate how dopamine affects the stress response, we used a zebrafish model that was exposed to stress. Methodology For three minutes, zebrafish were continually subjected to chasing stress. They were then given antibiotic combinations of 50 µg/mL each of vancomycin and omadacycline at various ratios of 1:1, 3:1, and 3:1. Behavior alterations, including freezing bouts, top-bottom ratios, and latency periods, were analyzed and contrasted with control groups. ImageJ software was utilized to analyze the video footage of the fish. Results The study showed that the combination of omadacycline and vancomycin greatly reduced the behaviors in zebrafish caused by stress. They chose their concentration (50 µg/mL) according to the lethal concentration 50% result. By shortening the latency time and increasing the intensity of breezing sessions, these chemicals restored almost normal activity. There was statistical significance in the outcomes. The results show that the combination of vancomycin and omadacycline may have an anti-psychotic impact on zebrafish behaviors brought on by stress. Their control of stress reactions is consistent with their known roles in the reward and stress circuits of the brain. These results emphasize the complex interactions between neurotransmitter systems and the control of stress, highlighting the therapeutic potential of dopamine in the treatment of stress-related mental illnesses. Conclusions The combination of vancomycin and omadacycline has been shown to have anti-psychotic effects, which presents potential opportunities for the development of new treatment strategies for mental diseases associated with stress. To fully understand the specific processes underpinning their involvement in stress management and how they relate to mental illnesses in humans, more investigation is necessary.

Female genital mutilation: trends, economic burden of delay and basis for public health interventions.

BACKGROUND: The practice of female genital mutilation (FGM) is a health and social problem. Millions of girls and women have undergone FGM or will soon, and more information is needed to effectively reduce the practice. The aim of this research is to provide an overview of the FGM trendlines, the inequality of its prevalence, and the economic burden. The findings shed light on 30-year trends and the impact of the pandemic on planned efforts to reduce FGM which helps with public health interventions. METHODS: Temporal trend analysis, and graphical analysis were used to assess the change and inequality over the last 30 years. We included 27 countries in which FGM is prevalent. We calculated the extra economic burden of delayed interventions to reduce FGM like COVID-19. RESULTS: For the 27 countries analyzed for temporal trendlines, 13 countries showed no change over time while 14 had decreasing trends. Among the 14, nine countries, Uganda, Togo, Ghana, Benin, Kenya, Nigeria, Central African Republic, Chad, and Ethiopia had high year-decrease (CAGR - 1.01 and - 10.26) while five, Côte d'Ivoire, Egypt, Gambia, Djibouti, and Mali had low year-decrease (CAGR>-1 and < 0). Among these five are the highest FGM prevalence similar distribution regardless the wealth quintiles or residence. There is an economic burden of delay or non-decline of FGM that could be averted. CONCLUSION: Findings indicate that some countries show a declining trend over time while others not. It can be observed that there is heterogeneity and homogeneity in the FGM prevalence within and between countries which may indicate inequality that deserves further investigation. There is considerable economic burden due to delays in the implementation of interventions to reduce or eliminate FGM. These insights can help in the preparation of public health interventions.

Mapping sustainable supply chain innovation: A comprehensive bibliometric analysis.

This comprehensive bibliometric study investigates Sustainable Supply Chain Innovation (SSCI) research, examining its evolution, identifying key contributors, and unveiling emerging trends. Analyzing 1158 English-language SSCI articles using the robust Scopus dataset exposes noteworthy journals, authors, institutions, and global contributions. The findings suggest a consistent increase in research output since 1999, with a notable surge in the past decade. Network analysis and density-based spatial clustering identified six SSCI research clusters: Sustainability and Responsibility in Business, Navigating Innovation and Disruption, Sustainable Business Strategies, Environmental Sustainability and Innovation, Sustainable Food Systems and Environmental Impact, and Sustainable Business Dynamics. These clusters highlight the diverse nature of the evolving Sustainability and Supply Chain Management (SCM) field, contributing to a thorough understanding of the SSCI research landscape and emphasizing interconnections between sustainability and SCM themes, potentially leading to more comprehensive theoretical models. Furthermore, this understanding aids businesses in anticipating emerging trends and implementing optimal practices in SSCI. Moreover, recognizing active institutions and global contributors provides practical insights for fostering strategic collaborations.

Mitigating air pollution benefits multiple sustainable development goals in China.

Achieving the United Nations 2030 Sustainable Development Goals (SDGs) remains a significant challenge, necessitating urgent and prioritized strategies. Among the various challenges, air pollution continues to pose one of the most substantial threats to the SDGs due to its widespread adverse effects on human health and ecosystems. However, the connections between air pollution and the SDGs have often been overlooked. This study reveals that out of the 169 SDG targets, 71 are adversely impacted by air pollution, while only 6 show potential positive effects. In China, two major atmospheric nitrogen pollutants, ammonia and nitrogen oxides, resulted in an economic loss of 400 billion United States Dollar (USD) in 2020, which could be reduced by 33% and 34% by 2030, respectively. It would enhance the progress towards SDGs in China by 14%, directly contributing to the achievement of SDGs 1 to 6 and 11 to 15. This improvement is estimated to yield overall benefits totaling 119 billion USD, exceeded the total implementation cost of 82 billion USD with ammonia as the preferential mitigation target. This study underscores the importance of robust scientific evidence in integrated policies aimed at aligning improvements in environmental quality with the priorities of sustainable development.

How urban growth dynamics impact the air quality? A case of eight Indian metropolitan cities.

Air pollution is a matter of great significance that confronts the sustainable progress of urban areas. Against India's swift urbanization, several urban areas exhibit the coexistence of escalating populace and expansion in developed regions alongside extensive spatial heterogeneity. The interaction mechanism between the growth of urban areas and the expansion of cities holds immense importance for the remediation of air pollution. Henceforth, the present investigation utilizes geographically weighted regression (GWR) to examine the influence of urban expansion and population growth on air quality. The examination will use a decade of data on the variation in PM2.5 levels from 2010 to 2020 in eight Indian metropolitan cities. The study's findings demonstrate a spatial heterogeneity between urban growth dynamics and air pollution levels. Urban growth and the expansion of towns demonstrate notable positive impacts on air quality, although the growth of infilling within expanding urban areas can significantly affect air quality. Given the unique trajectories of urban development in developing countries, this research provides many suggestions for urban administrators to foster sustainable urban growth.

Causes and consequences of tipping points in river delta social-ecological systems.

The sustainability of social-ecological systems within river deltas globally is in question as rapid development and environmental change trigger "negative" or "positive" tipping points depending on actors' perspectives, e.g. regime shift from abundant sediment deposition to sediment shortage, agricultural sustainability to agricultural collapse or shift from rural to urban land use. Using a systematic review of the literature, we show how cascading effects across anthropogenic, ecological, and geophysical processes have triggered numerous tipping points in the governance, hydrological, and land-use management of the world's river deltas. Crossing tipping points had both positive and negative effects that generally enhanced economic development to the detriment of the environment. Assessment of deltas that featured prominently in the review revealed how outcomes of tipping points can inform the long-term trajectory of deltas towards sustainability or collapse. Management of key drivers at the delta scale can trigger positive tipping points to place social-ecological systems on a pathway towards sustainable development.

Sensors on Internet of Things Systems for the Sustainable Development of Smart Cities: A Systematic Literature Review.

The Internet of Things (IoT) is a critical component of smart cities and a key contributor to the achievement of the United Nations Sustainable Development Goal (UNSDG) 11: Sustainable Cities and Communities. The IoT is an infrastructure that enables devices to communicate with each other over the Internet, providing critical components for smart cities, such as data collection, generation, processing, analysis, and application handling. IoT-based applications can promote sustainable urban development. Many studies demonstrate how the IoT can improve smart cities' sustainable development. This systematic literature review provides valuable insights into the utilization of the IoT in the context of smart cities, with a particular focus on its implications for sustainable urban development. Based on an analysis of 73 publications, we discuss the role of IoT in the sustainable development of smart cities, focusing on smart communities, smart transportation, disaster management, privacy and security, and emerging applications. In each domain, we have detailed the attributes of IoT sensors. In addition, we have examined various communication technologies and protocols suitable for transmitting sensor-generated data. We have also presented the methods for analyzing and integrating these data within the IoT application layer. Finally, we identify research gaps in the literature, highlighting areas that require further investigation.

Effects of COVID-19 on coastal and marine environments: Aggravated microplastic pollution, improved air quality, and future perspective.

The COVID-19 pandemic during 2020-2023 has wrought adverse impacts on coastal and marine environments. This study conducts a comprehensive review of the collateral effects of COVID-19 on these ecosystems through literature review and bibliometric analysis. According to the output and citation analysis of these publications, researchers from the coastal countries in Asia, Europe, and America payed more attentions to this environmental issue than other continents. Specifically, India, China, and USA were the top three countries in the publications, with the proportion of 19.55%, 18.99%, and 12.01%, respectively. The COVID-19 pandemic significantly aggravated the plastic and microplastic pollution in coastal and marine environments by explosive production and unproper management of personal protective equipment (PPE). During the pandemic, the estimated mismanaged PPE waste ranged from 16.50 t/yr in Sweden to 250,371.39 t/yr in Indonesia. In addition, the PPE density ranged from 1.13 × 10-5 item/m2 to 2.79 item/m2 in the coastal regions worldwide, showing significant geographical variations. Besides, the emerging contaminants released from PPE into the coastal and marine environments cannot be neglected. The positive influence was that the COVID-19 lockdown worldwide reduced the release of air pollutants (e.g., fine particulate matter, NO2, CO, and SO2) and improved the air quality. The study also analyzed the relationships between sustainable development goals (SDGs) and the publications and revealed the dynamic changes of SDGs in different periods the COVID-19 pandemic. In conclusion, the air was cleaner due to the lockdown, but the coastal and marine contamination of plastic, microplastic, and emerging contaminants got worse during the COVID-19 pandemic. Last but not least, the study proposed four strategies to deal with the coastal and marine pollution caused by COVID-19, which were regular marine monitoring, performance of risk assessment, effective regulation of plastic wastes, and close international cooperation.

Evaluation of sustainable development capacity of water sources: a case study of China.

The issue of water scarcity has drawn attention from all over the world. The coordination of the interaction between ecological and environmental development of water sources and socio-economic development is currently an essential issue that needs to be solved in order to safeguard the water resources environment for human survival. In this essay, we suggest a paradigm for assessing the sustainable exploitation of water resources. First, three ecological, economic, and social factors are investigated. Twenty essential evaluation indexes are then constructed using the Delphi approach, along with an index system for assessing the potential of water sources for sustainable development. The weights of each evaluation index were then determined using the combination assignment approach, which was then suggested. The coupled degree evaluation model of the capability for sustainable development of water sources was then developed. In order to confirm the viability and validity of the suggested model, the model was used to assess the Liwu River water source's capacity for sustainable growth in the context of the South-North Water Transfer in Shandong, China. It is believed that the aforementioned study would serve as a helpful resource when evaluating the capacity of water sources for sustainable development.

A comprehensive review of the environmental benefits of urban green spaces.

This detailed analysis highlights the numerous environmental benefits provided by urban green spaces, emphasizing their critical role in improving urban life quality and advancing sustainable development. The review delves into critical themes such as the impact of urban green spaces on human health, the complex interplay between urban ecology and sustainability, and the evaluation of ecosystem services using a comprehensive review of existing literature. The investigation thoroughly examines various aspects of green infrastructure, shedding light on its contributions to social cohesion, human well-being, and environmental sustainability in general. The analysis summarizes the study's findings and demonstrates the critical role of urban green spaces in urban ecology, which significantly mitigates environmental challenges. The intricate links between these green spaces and human health are thoroughly investigated, with benefits ranging from enhanced mental and physical well-being to comprehensive mental health. Furthermore, the analysis emphasizes how green spaces benefit urban development by increasing property values, boosting tourism, and creating job opportunities. The discussion also considers possible futures, emphasizing the integration of technology, the advancement of natural solutions, and the critical importance of prioritizing health and well-being in the design of urban green spaces. To ensure that urban green spaces are developed and maintained as essential components of resilient and sustainable urban environments, the assessment concludes with practical recommendations for communities, urban planners, and legislators.

GIS-based intelligent planning approach of child-friendly pedestrian pathway to promote a child-friendly city.

Pedestrian safety, particularly for children, relies on well-designed pathways. Child-friendly pathways play a crucial role in safeguarding young pedestrians. Shared spaces accommodating both vehicles and walkers can bring benefits to pedestrians. However, active children playing near these pathways are prone to accidents. This research aims to develop an efficient method for planning child-friendly pedestrian pathways, taking into account community development and the specific needs of children. A mixed-methods approach was employed, utilizing the Datang community in Guangzhou, China, as a case study. This approach combined drawing techniques with GIS data analysis. Drawing methods were utilized to identify points of interest for children aged 2-6. The qualitative and quantitative fuzzy analytic hierarchy process assessed factors influencing pathway planning, assigning appropriate weights. The weighted superposition analysis method constructed a comprehensive cost grid, considering various community elements. To streamline the planning process, a GIS tool was developed based on the identified factors, resulting in a practical, child-friendly pedestrian pathway network. Results indicate that this method efficiently creates child-friendly pathways, ensuring optimal connectivity within the planned road network.

Exposure to benzene, toluene, ethylbenzene, and xylene (BTEX) at Nigeria's petrol stations: a review of current status, challenges and future directions.

Introduction: In Nigeria, because of increasing population, urbanization, industrialization, and auto-mobilization, petrol is the most everyday non-edible commodity, and it is the leading petroleum product traded at the proliferating Nigeria's petrol stations (NPSs). However, because of inadequate occupational health and safety (OHS) regulatory measures, working at NPSs exposes petrol station workers (PSWs) to a large amount of hazardous benzene, toluene, ethylbenzene, and xylene (BTEX) compounds. Methods: Studies on BTEX exposures among Nigerian PSWs are scarce. Thus, constraints in quantifying the health risks of BTEX limit stakeholders' ability to design practical risk assessment and risk control strategies. This paper reviews studies on the OHS of Nigerian PSWs at the NPSs. Results: Although knowledge, attitude, and practices on OHS in NPSs vary from one Nigeria's study setting to another, generally, safety practices, awareness about hazards and personal protective equipment (PPE), and the use of PPE among PSWs fell below expectations. Additionally, air quality at NPSs was poor, with a high content of BTEX and levels of carbon monoxide, hydrogen sulfide, particulate matter, and formaldehyde higher than the World Health Organization guideline limits. Discussion: Currently, regulatory bodies' effectiveness and accountability in safeguarding OHS at NPSs leave much to be desired. Understanding the OHS of NPSs would inform future initiatives, policies, and regulations that would promote the health and safety of workers at NPSs. However, further studies need to be conducted to describe the vulnerability of PSWs and other Nigerians who are occupationally exposed to BTEX pollution. More importantly, controlling air pollution from hazardous air pollutants like BTEX is an essential component of OHS and integral to attaining the Sustainable Development Goals (SDG) 3, 7, and 11.

Powering the Future by Iron Sulfide Type Material (FexSy) Based Electrochemical Materials for Water Splitting and Energy Storage Applications: A Review.

Water electrolysis is among the recent alternatives for generating clean fuels (hydrogen). It is an efficient way to produce pure hydrogen at a rapid pace with no unwanted by-products. Effective and cheap water-splitting electrocatalysts with enhanced activity, specificity, and stability are currently widely studied. In this regard, noble metal-free transition metal-based catalysts are of high interest. Iron sulfide (FeS) is one of the essential electrocatalysts for water splitting because of its unique structural and electrochemical features. This article discusses the significance of FeS and its nanocomposites as efficient electrocatalysts for oxygen evolution reaction (OER), hydrogen evolution reaction (HER), oxygen reduction reaction (ORR), and overall water splitting. FeS and its nanocomposites have been studied also for energy storage in the form of electrode materials in supercapacitors and lithium- (LIBs) and sodium-ion batteries (SIBs). The structural and electrochemical characteristics of FeS and its nanocomposites, as well as the synthesis processes, are discussed in this work. This discussion correlates these features with the requirements for electrocatalysts in overall water splitting and its associated reactions. As a result, this study provides a road map for researchers seeking economically viable, environmentally friendly, and efficient electrochemical materials in the fields of green energy production and storage.

Navigating sustainable horizons: exploring the dynamics of financial stability, green growth, renewable energy, technological innovation, financial inclusion, and soft infrastructure in shaping sustainable development.

This paper examines sustainable development, which employs an integrated approach to tackle environmental, social, and economic challenges. It provides a theoretical underpinning by examining sustainable development's inception, fundamental tenets, and conceptual structures. This study highlights the interdependence of social equity, economic prosperity, and environmental conservation, emphasizing the need for a comprehensive approach. Quantitative methodology is utilized in this study, and the dependent variable is sustainable development. Financial risk, green growth, technological innovation, renewable energy, financial inclusion, and soft infrastructure are all independent variables. The analysis is predicated on secondary data from the Organization for Economic Cooperation and Development and World Development Indicators databases spanning 2004 to 2019. An entropy-weighted method used for the green growth index is a metric that enhances the precision of variable indicators. Cointegration, correlation, VIF, cross-sectional dependency, and stationarity tests are among the diagnostic tests that inform the selection of methods for the panel data set. It is determined that fully modified ordinary least squares is the suitable technique. The findings suggest statistically significant positive correlations among greenhouse gases, financial inclusion, and soft infrastructure. Conversely, significant negative correlations exist between financial risk, green growth, renewable energy, and technological innovation. An estimated 55% long-run variance is present. The study's key finding is that financial risk has an adverse effect on sustainable development, while an impactful relationship where increased green growth is linked to decreased GHG emissions. This association is notably significant. Results show that renewable energy has a negative coefficient and significant negative impact on greenhouse gases, showing an active relation to enhancing sustainable development. In contrast, financial inclusion has a significant positive effect on sustainable development. The implications imply that providing incentives to institutions engaged in alternative energy, precisely renewable sources, could positively impact the environment. Government policies and funding regulations oriented toward sustainable development are indispensable for environmental sustainability. Government policies and incentives are pivotal in advancing an environmentally conscious and sustainable future. This study's contribution lies in elucidating the positive correlation between government interventions and promoting renewable energy adoption, thereby paving the way for a greener tomorrow.

Unveiling insights: A dataset analysis of Islamic quality management systems in educational institutions toward SDG-aligned education.

This article presents data derived from a survey conducted to assess the validity and reliability of a newly developed instrument for Quality Management System items in the context of educational institutions. By analyzing the descriptive statistics, a concise overview of the main characteristics of the data set is provided, which facilitates the implementation and interpretation of the newly developed Quality Management System. Considering the need for quality education highlighted in the United Nations Sustainable Development Goals, organizations need to prioritize quality management, which can be achieved through the implementation of Quality Management Systems. The present data set focuses on Islamic Quality Management Systems in Malaysian educational institutions and includes responses from 35 Islamic private elementary school in different states in Malaysia. This dataset covers a wide range of variables relevant to the education sector and provides valuable insights for education stakeholders and curriculum developers. By aligning with the principles of quality education advocated by the SDGs, these findings offer significant opportunities to support educators and improve the quality of education.

Top 100 highly cited sustainability researchers.

The announcement of the UN Sustainable Development Goals (SDGs) provided a fresh direction to sustainability research that spans different disciplines. Consequently, scholarly databases made available the mapping of research publications to different SDGs, unleashing many opportunities for analysis. In this work, the top 100 Highly Cited Sustainability Researchers (HCSRs) and information related to them, such as the institutions they belong to, the type of these institutions, the geographical diversity of these researchers, and gender representation patterns, are analyzed. Also, from their publications, their publication pattern, including (i) the least and most researched SDGs, (ii) their Open Access publishing pattern, (iii) their collaboration pattern (iv) the pattern of their research impact, are analyzed. The most sought thematic areas of their research, top journals in which they publish, important research categories handled by these journals, etc., are also investigated. The most significant contribution of these researchers and their recent contributions are also discussed. The data indicates a significant disparity in research focus among the top 100 HCSRs, with most concentrating on "Good Health and Well Being," "Zero Hunger," and "Quality Education," while notably fewer researchers focus on "Decent Work and Economic Growth" and "No Poverty," underscoring the need for a more balanced research agenda across all SDGs. The study reveals that the United States, China, and the United Kingdom are the leading contributors to the top 100 HCSRs, suggesting that these countries are predominant in global sustainability research output, while nations like Iran and Saudi Arabia also make notable, albeit smaller, contributions. The institutional affiliations of HCSRs show a significant imbalance, with only 16 from private institutions compared to 84 from public ones. Specifically, it shows that out of the top 100 researchers, 93 are men, while only 7 are women. The analysis of authorship in publications by HCSRs reveals a tendency towards middle and last author positions, underscoring their collaborative and leadership roles within the research community. All these analyses can inform academia, industry, and policymakers about the most significant developments in research regarding SDGs.

Knowledge, Attitudes and Practices of Chagas a Neglected Tropical Disease in Rural Communities of the Colombian Caribbean, CHAGCOV Study.

PURPOSE: Chagas disease (CD) a Neglected Tropical Diseases is an important public health issue in countries where is still endemic, included in the Sustainable Development Goals (SDG). Traditionally restricted to rural areas with diverse routes of transmissions from vectorial to oral with acute manifestations but being more common diagnosed in chronic stages. The aim of this investigation was to characterize the Knowledge, Attitudes and Practices (KAP) related to Chagas disease (CD) in two rural settlements of the Colombian Caribbean with previous records of the disease and/or the parasite. METHODS: A cross-sectional descriptive study was made in two rural settlements in Colombia and surveillance instrument was developed to measure Knowledge, Attitudes and Practices (KAP) related to Chagas disease (CD). RESULTS: In a population with > 60% women and access to social security around 66.5%; 81,6% were homeowners with access to water and electricity > 90% but only 9% of sewerage. The level of knowledge about CD was around 62% but lack of specificity about comprehension of transmission routes (74,6%), and symptoms (85,3%) were found; concluding that 86% of the surveyed sample had very poor level of knowledge about the disease despite preventive campaigns carried out in the two communities studied. CONCLUSIONS: Despite of a low frequency of CD in this Caribbean areas, the presence of vector, risk factors plus poor level of knowledge about the disease justify that public health intervention strategies should be implemented and monitored over time to maintain uninterrupted surveillance of Chagas Disease.

Evaluating plans for sustainable development in Arctic cities.

Cities located in the Arctic often have extreme geographic and environmental contexts and unique sociopolitical and economic trajectories that, when combined with amplified effects of climate change in the region, impact future sustainable development. Well-recognized and standardized sustainable development indicator (SDI) frameworks such as ISO 37120 or UN-Habitat City Prosperity Index are often used to compare data across cities globally using comprehensive sets of indicators. While such indexes help characterize progress toward development and guide short- and long-term decision-making, they often lack relevance to specific contexts or characterize future visions of urban growth. To evaluate the extent of these deficiencies and to provide a comparative analysis of approaches to sustainable urban growth in the Arctic, this paper analyzes city planning documents for five northern cities - Anchorage (USA), Utqiagvik (USA), Reyjavik (ISL), Iqaluit, (CAN), Whitehorse, (CAN) - for goals, targets, and indicators and compare these to thematic areas and indicators defined by ISO 37120:2018 Sustainable Cities and Communities. The results confirm that although international SDI frameworks may be useful for comparative analysis of cities across diverse regions, they exclude important local factors that influence goal-oriented urban sustainability planning strategies employed in the Arctic region.